Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.

@article{Storer2013ZebrafishRR,
  title={Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.},
  author={Narie Yoo Storer and Richard M White and Audrey Uong and Emily J Price and Gunnlager Petur Nielsen and David M Langenau and Leonard I. Zon},
  journal={Development},
  year={2013},
  volume={140 14},
  pages={
          3040-50
        }
}
Rhabdomyosarcoma is a pediatric malignancy thought to arise from the uncontrolled proliferation of myogenic cells. Here, we have generated models of rhabdomyosarcoma in the zebrafish by inducing oncogenic KRAS(G12D) expression at different stages during muscle development. Several zebrafish promoters were used, including the cdh15 and rag2 promoters, which drive gene expression in early muscle progenitors, and the mylz2 promoter, which is expressed in differentiating myoblasts. The tumors that… CONTINUE READING
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