Zebrafish retinoic acid receptors function as context-dependent transcriptional activators.

@article{Waxman2011ZebrafishRA,
  title={Zebrafish retinoic acid receptors function as context-dependent transcriptional activators.},
  author={Joshua S Waxman and Deborah Yelon},
  journal={Developmental biology},
  year={2011},
  volume={352 1},
  pages={128-40}
}
RA receptors (RARs) have been thought to function through a binary repressor-activator mechanism: in the absence of ligand, they function as transcriptional repressors, and, in the presence of ligand, they function as transcriptional activators. This prevailing model of RAR mechanism has been derived mostly from in vitro studies and has not been widely tested in developmental contexts. Here, we investigate whether zebrafish RARs function as transcriptional activators or repressors during early… CONTINUE READING