Zebrafish rest regulates developmental gene expression but not neurogenesis.

  title={Zebrafish rest regulates developmental gene expression but not neurogenesis.},
  author={Fatma O. Kok and Andrew Taibi and Sarah J Wanner and Xiayang Xie and Cara E Moravec and C. Ernie Love and Victoria E. Prince and Jeff S Mumm and Howard I Sirotkin},
  volume={139 20},
The transcriptional repressor Rest (Nrsf) recruits chromatin-modifying complexes to RE1 'silencer elements', which are associated with hundreds of neural genes. However, the requirement for Rest-mediated transcriptional regulation of embryonic development and cell fate is poorly understood. Conflicting views of the role of Rest in controlling cell fate have emerged from recent studies. To address these controversies, we examined the developmental requirement for Rest in zebrafish using zinc… CONTINUE READING
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