Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development

@article{Faucherre2008ZebrafishPG,
  title={Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development},
  author={Ad{\`e}le Faucherre and Gregory S. Taylor and John Overvoorde and James E Dixon and Jeroen den Hertog},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={1079-1086}
}
In human cancer, PTEN (Phosphatase and TENsin homolog on chromosome 10, also referred to as MMAC1 and TEP1) is a frequently mutated tumor suppressor gene. We have used the zebrafish as a model to investigate the role of Pten in embryonic development and tumorigenesis. The zebrafish genome encodes two pten genes, ptena and ptenb. Here, we report that both Pten gene products from zebrafish are functional. Target-selected inactivation of ptena and ptenb revealed that Ptena and Ptenb have redundant… CONTINUE READING

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