Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.

@article{Nica2004ZebrafishPM,
  title={Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.},
  author={Gabriela Nica and Wiebke Herzog and Carmen Sonntag and Matthias Hammerschmidt},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 5},
  pages={1196-209}
}
The Pou domain transcription factor Pit-1 is required for lineage determination and cellular commitment processes during mammalian adenohypophysis development. Here we report the cloning and mutational analysis of a pit1 homolog from zebrafish. Compared with mouse, zebrafish pit1 starts to be expressed at a much earlier stage of adenohypophysis development. However, as in the mouse, expression is restricted to a subset of pituitary cell types, excluding proopiomelanocortin (pomc)-expressing… CONTINUE READING