Zebrafish narrowminded disrupts the transcription factor prdm1 and is required for neural crest and sensory neuron specification.

@article{HernandezLagunas2005ZebrafishND,
  title={Zebrafish narrowminded disrupts the transcription factor prdm1 and is required for neural crest and sensory neuron specification.},
  author={Laura Hernandez-Lagunas and Irene F Choi and Takao Kaji and Peter A. Simpson and Candice Hershey and Yi Zhou and Len I Zon and M. Mercola and Kristin Bruk Artinger},
  journal={Developmental biology},
  year={2005},
  volume={278 2},
  pages={347-57}
}
Specification of both neural crest cells and Rohon-Beard (RB) sensory neurons involves a complex series of interactions between the neural and non-neural ectoderm. The molecular mechanisms directing this process are not well understood. The zebrafish narrowminded (nrd) mutation is unique, since it is one of two mutations in which defects are observed in both cell populations: it leads to a complete absence of RB neurons and a reduction in neural crest cells and their derivatives. Here, we show… CONTINUE READING
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