Zebrafish models of human motor neuron diseases: Advantages and limitations

  title={Zebrafish models of human motor neuron diseases: Advantages and limitations},
  author={Patrick J. Babin and Cyril Goizet and Demetrio Rald{\'u}a},
  journal={Progress in Neurobiology},
Motor neuron diseases (MNDs) are an etiologically heterogeneous group of disorders of neurodegenerative origin, which result in degeneration of lower (LMNs) and/or upper motor neurons (UMNs). Neurodegenerative MNDs include pure hereditary spastic paraplegia (HSP), which involves specific degeneration of UMNs, leading to progressive spasticity of the lower limbs. In contrast, spinal muscular atrophy (SMA) involves the specific degeneration of LMNs, with symmetrical muscle weakness and atrophy… CONTINUE READING


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Zebrafish as a model system for successful spinal cord regeneration

  • C. G. Becker, T. Becker
  • Model Organisms in Spinal Cord Regeneration…
  • 2007
Highly Influential
4 Excerpts

The organization of movement

  • C. Ghez, J. Krakauer
  • Principles of Neural Science. McGraw-Hill,
  • 2000
Highly Influential
4 Excerpts

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