Zebrafish limb development is triggered by a retinoic acid signal during gastrulation.

@article{Grandel2011ZebrafishLD,
  title={Zebrafish limb development is triggered by a retinoic acid signal during gastrulation.},
  author={Heiner Grandel and Michael Brand},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2011},
  volume={240 5},
  pages={1116-26}
}
Studies in mouse and zebrafish show that vertebrate forelimb development is initiated by retinoic acid (RA). An RA signal leads to transcription of tbx5 in forelimb precursors which is necessary and sufficient for limb development. However, the timing of the RA signaling event has remained controversial as have source tissue and tissue interactions. We have thus determined the contribution of RA to zebrafish pectoral fin development at different developmental stages. Specifically, an early… CONTINUE READING
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