Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism

Abstract

BACKGROUND DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this kinase-encoding gene have been reported to cause microcephaly associated with either intellectual disability or autism in humans. Intellectual disability accompanied by microcephaly was recapitulated in a murine model by overexpressing Dyrk1a which mimicked Down syndrome… (More)
DOI: 10.1186/s13229-017-0168-2

Topics

7 Figures and Tables