Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis.

@article{Blake2000ZebrafishHO,
  title={Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis.},
  author={Trevor B. Blake and Neeraj Adya and Chang Hyun Kim and Andrew C Oates and Leonard Zon and Ajay Chitnis and Brant M Weinstein and Pu Liu},
  journal={Blood},
  year={2000},
  volume={96 13},
  pages={4178-84}
}
Mammalian CBFB encodes a transcription factor (CBF beta) that in combination with CBF alpha 2 binds to specific DNA sequences and regulates expression of a number of hematopoietic genes. CBFB is associated with human leukemias through a chromosome 16 inversion and is essential for definitive hematopoiesis during mouse embryo development. We have isolated a zebrafish cbfb complementary DNA (cDNA) clone from a zebrafish kidney cDNA library. This cbfb is highly homologous to human and mouse CBFB… CONTINUE READING

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