Zebrafish heart failure models for the evaluation of chemical probes and drugs.

@article{Huang2013ZebrafishHF,
  title={Zebrafish heart failure models for the evaluation of chemical probes and drugs.},
  author={Cheng-Chen Huang and Aaron Monte and James M Cook and Mohd Shahjahan Kabir and Karl P Peterson},
  journal={Assay and drug development technologies},
  year={2013},
  volume={11 9-10},
  pages={561-72}
}
Heart failure is a complex disease that involves genetic, environmental, and physiological factors. As a result, current medication and treatment for heart failure produces limited efficacy, and better medication is in demand. Although mammalian models exist, simple and low-cost models will be more beneficial for drug discovery and mechanistic studies of heart failure. We previously reported that aristolochic acid (AA) caused cardiac defects in zebrafish embryos that resemble heart failure… CONTINUE READING

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