Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish.

@article{Bessa2009ZebrafishED,
  title={Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish.},
  author={Jos{\'e} Elievam Bessa and Juan J. Tena and Elisa de la Calle-Mustienes and Ana Fern{\'a}ndez-Mi{\~n}{\'a}n and Silvia Naranjo and Almudena Fern{\'a}ndez and Lluis Montoliu and Altuna Akalin and Boris Lenhard and Fernando Casares and Jos{\'e} Luis G{\'o}mez-Skarmeta},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={238 9},
  pages={2409-17}
}
The identification and characterization of the regulatory activity of genomic sequences is crucial for understanding how the information contained in genomes is translated into cellular function. The cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe a novel Tol2 transposon-based vector for assessing enhancer activity in the zebrafish (Danio rerio). This Zebrafish Enhancer… CONTINUE READING

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