Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates.

@article{Dutton2001ZebrafishCE,
  title={Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates.},
  author={Kirsten A Dutton and Angela Pauliny and Susana Santos Lopes and Stone Elworthy and Tom J Carney and Jens Rauch and Robert Geisler and Pascal Haffter and Robert N Kelsh},
  journal={Development},
  year={2001},
  volume={128 21},
  pages={4113-25}
}
Waardenburg-Shah syndrome combines the reduced enteric nervous system characteristic of Hirschsprung's disease with reduced pigment cell number, although the cell biological basis of the disease is unclear. We have analysed a zebrafish Waardenburg-Shah syndrome model. We show that the colourless gene encodes a sox10 homologue, identify sox10 lesions in mutant alleles and rescue the mutant phenotype by ectopic sox10 expression. Using iontophoretic labelling of neural crest cells, we demonstrate… CONTINUE READING
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