Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning.

@article{Nixon2005ZebrafishAA,
  title={Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning.},
  author={Susan J. Nixon and Jeremy Wegner and Charles H. Ferguson and P. -F. M{\'e}ry and John F Hancock and Peter David Currie and B Key and Monte Westerfield and Robert G. Parton},
  journal={Human molecular genetics},
  year={2005},
  volume={14 13},
  pages={1727-43}
}
Caveolae are an abundant feature of many animal cells. However, the exact function of caveolae remains unclear. We have used the zebrafish, Danio rerio, as a system to understand caveolae function focusing on the muscle-specific caveolar protein, caveolin-3 (Cav3). We have identified caveolin-1 (alpha and beta), caveolin-2 and Cav3 in the zebrafish. Zebrafish Cav3 has 72% identity to human CAV3, and the amino acids altered in human muscle diseases are conserved in the zebrafish protein. During… CONTINUE READING

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