Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.

@article{Cheesman2004ZebrafishAF,
  title={Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.},
  author={Sarah E. Cheesman and Michael J. Layden and Tonia Von Ohlen and Chris Q Doe and Judith S Eisen},
  journal={Development},
  year={2004},
  volume={131 21},
  pages={5221-32}
}
Genes belonging to the Nkx, Gsh and Msx families are expressed in similar dorsovental spatial domains of the insect and vertebrate central nervous system (CNS), suggesting the bilaterian ancestor used this genetic program during CNS development. We have investigated the significance of these similar expression patterns by testing whether Nkx6 proteins expressed in ventral CNS of zebrafish and flies have similar functions. In zebrafish, Nkx6.1 is expressed in early-born primary and later-born… CONTINUE READING

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