Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs.

@article{Dahlman2005ZebrafishAP,
  title={Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs.},
  author={Jason M Dahlman and Kelli L Margot and Linlin Ding and Joseph Horwitz and Mason Posner},
  journal={Molecular vision},
  year={2005},
  volume={11},
  pages={88-96}
}
PURPOSE The vertebrate small heat shock proteins alphaA- and alphaB-crystallin contribute to the transparency and refractive power of the lens and may also prevent the aggregation of non-native proteins that would otherwise lead to cataracts. We previously showed that zebrafish (Danio rerio) and human alphaB-crystallin have diverged far more in primary structure and expression pattern than the orthologous alphaA-crystallins. In this current study we further compare the structure and function of… CONTINUE READING

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