Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.

@article{Lieschke2002ZebrafishS,
  title={Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning.},
  author={Graham J. Lieschke and Andrew C Oates and Barry H Paw and Margaret Anne Thompson and Nathan E. Hall and Alister C Ward and Robert K. H. Ho and Leonard I. Zon and Judith E. Layton},
  journal={Developmental biology},
  year={2002},
  volume={246 2},
  pages={
          274-95
        }
}
The mammalian transcription factor SPI-1 (synonyms: SPI1, PU.1, or Sfpi1) plays a critical role in myeloid development. To examine early myeloid commitment in the zebrafish embryo, we isolated a gene from zebrafish that is a SPI-1 orthologue on the basis of homology and phylogenetic considerations. The zebrafish spi1 (pu1) gene was first expressed at 12 h postfertilization in rostral lateral plate mesoderm (LPM), anatomically isolated from erythroid development in caudal lateral plate mesoderm… CONTINUE READING
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