Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development

@inproceedings{Onichtchouk2010ZebrafishPT,
  title={Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development},
  author={Daria Onichtchouk and Florian Geier and Bożena K. Polok and Daniel M Messerschmidt and Rebecca M{\"o}ssner and Bj{\"o}rn Wendik and Sungmin Song and Verdon Taylor and Jens Timmer and Wolfgang Driever},
  booktitle={Molecular systems biology},
  year={2010}
}
The transcription factor POU5f1/OCT4 controls pluripotency in mammalian ES cells, but little is known about its functions in the early embryo. We used time-resolved transcriptome analysis of zebrafish pou5f1 MZspg mutant embryos to identify genes regulated by Pou5f1. Comparison to mammalian systems defines evolutionary conserved Pou5f1 targets. Time-series data reveal many Pou5f1 targets with delayed or advanced onset of expression. We identify two Pou5f1-dependent mechanisms controlling… CONTINUE READING
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