Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.

@article{Gardiner2005ZebrafishKI,
  title={Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.},
  author={Melissa R Gardiner and David F. Daggett and Leonard I. Zon and Andrew C. Perkins},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2005},
  volume={234 4},
  pages={
          992-6
        }
}
Gene knockout studies of Krüppel-like factors (KLFs) in mice have shown essential roles in organogenesis. A screen for KLF family members in zebrafish identified many KLFs. One of these, zebrafish KLF4 (zKLF4) is the homologue of neptune, a Xenopus laevis KLF. zKLF4 is expressed from approximately 80% epiboly a patch of dorsal/anterior mesendodermal cells called the pre-polster and, subsequently, in the polster and hatching gland. Here we investigate the function of zKLF4 using morpholino-based… CONTINUE READING

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