Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling.

@article{Feng2015ZebrafishIR,
  title={Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling.},
  author={Hui Feng and Yibing Zhang and Qi-Min Zhang and Zhi Li and Qiya Zhang and Jian-Fang Gui},
  journal={Journal of immunology},
  year={2015},
  volume={194 3},
  pages={1225-38}
}
In mammals, type I IFNs (mainly IFN-α/β) are primarily regulated by transcription factors of the IFN regulatory factor (IRF) family. Fish IFNs do not show a one-to-one orthologous relationship with mammalian type I IFN homologues. Using a bacterial one-hybrid reporter screening system and an overexpression approach to explore the molecular mechanism underlying fish IFN induction, we identified zebrafish Danio rerio IRF (DrIRF)1 as a positive regulator of the fish IFN antiviral response. Among… CONTINUE READING

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