Zebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plants

@inproceedings{Crawford2011ZebrafishBN,
  title={Zebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plants},
  author={Alexander D. Crawford and Sandra Liekens and Appolinary A R Kamuhabwa and Jan Willem Maes and Sebastian Munck and Roger Busson and Jef Rozenski and Camila V. Esguerra and Peter A. M. de Witte},
  booktitle={PloS one},
  year={2011}
}
Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of natural origin would benefit from therapeutically relevant bioassays capable of facilitating the isolation of bioactive molecules from multi-constituent extracts. Towards this end, we developed an in vivo bioassay-guided isolation approach for natural product discovery that combines bioactivity screening in zebrafish embryos with rapid… CONTINUE READING
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