Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.

@article{Copmans2018ZebrafishBasedDO,
  title={Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.},
  author={Dani{\"e}lle Copmans and Mostafa E. Rateb and Jioji N Tabudravu and Mercedes P{\'e}rez-Bonilla and Nina Dirkx and Riccardo Vallorani and Caridad D{\'i}az and Jos{\'e} P{\'e}rez del Palacio and Alan James Smith and Rainer Ebel and Fernando Reyes and Marcel Jaspars and Peter A. M. de Witte},
  journal={ACS chemical neuroscience},
  year={2018},
  volume={9 7},
  pages={
          1652-1662
        }
}
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further development. Within the framework of this project, seven known heterospirocyclic γ-lactams, namely, pseurotin A, pseurotin A2, pseurotin F1, 11- O-methylpseurotin A, pseurotin D, azaspirofuran A, and azaspirofuran B, were isolated from the bioactive… 
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