Zebrafish: An Emerging Model System for Human Disease and Drug Discovery

@article{Kari2007ZebrafishAE,
  title={Zebrafish: An Emerging Model System for Human Disease and Drug Discovery},
  author={G. Kari and U. Rodeck and A. Dicker},
  journal={Clinical Pharmacology & Therapeutics},
  year={2007},
  volume={82}
}
In vivo studies represent an essential step in drug development and currently rely largely on mice, yet limitations of mammalian models motivated the search for complementary vertebrate model systems. This review focuses on zebrafish, Danio rerio, as a facile model system to study human disease and drug responses. Zebrafish are particularly suited for this purpose because they represent a vertebrate species, their genome is sequenced, and a large number of synchronously developing, transparent… Expand
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