Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis

@article{Smit2011Zeb1IR,
  title={Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis},
  author={Marjon A. Smit and Daniel S Peeper},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={3735-3744}
}
Anoikis (detachment-induced apoptosis) prevents the survival of cells at inappropriate sites of the body and can therefore act as a barrier to metastasis. In a function-based genome-wide screen, we have previously identified the neurotrophic tyrosine kinase receptor TrkB as a potent suppressor of anoikis. Consistently, activated TrkB oncogenically transforms non-malignant epithelial cells and causes them to invade and produce metastatic tumors in vivo. Overexpression of activated TrkB also… CONTINUE READING
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