Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism.

@article{Mathow2015Zeb1AE,
  title={Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism.},
  author={Daniel Mathow and Federica Chessa and Mariona Costa Rabionet and Sylvia Kaden and Richard Jennemann and Roger Sandhoff and Hermann-Josef Gr{\"o}ne and Alexander Feuerborn},
  journal={EMBO reports},
  year={2015},
  volume={16 3},
  pages={
          321-31
        }
}
This study proposes that the transcription factor Zeb1 modulates epithelial cell adhesion by diverting glycosphingolipid metabolism. Zeb1 promotes expression of a-series glycosphingolipids via regulating expression of GM3 synthase (St3gal5), which mechanistically involves Zeb1 binding to the St3gal5 promoter as well as suppressing microRNA-mediated repression of St3gal5. Functionally, the repression of St3gal5 suffices to elevate intercellular adhesion and expression of distinct junction… CONTINUE READING
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The transcription factor ZEB 1 ( deltaEF 1 ) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

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