Zeaxanthin is bioavailable from genetically modified zeaxanthin-rich potatoes

  title={Zeaxanthin is bioavailable from genetically modified zeaxanthin-rich potatoes},
  author={Achim Bub and Jutta M{\"o}seneder and Gerhard Wenzel and Gerhard Rechkemmer and Karlis Briviba},
  journal={European Journal of Nutrition},
The carotenoid zeaxanthin accumulates in the human macula lutea and protects retinal cells from blue light damage. However, zeaxanthin intake from food sources is low. Increasing zeaxanthin in common foods such as potatoes by traditional plant breeding or by genetic engineering could contribute to an increased intake of this carotenoid and, consequently, to a decreased risk of age-related macular degeneration. Our aim was to investigate whether zeaxanthin from genetically modified zeaxanthin… 

Metabolic Biosynthesis of Potato (Solanum tuberosum l.) Antioxidants and Implications for Human Health

This review provides referenced summaries of all of the antioxidant groups present in potato tubers and updated schematics including genetic regulation for the major antioxidant biosynthesis pathways to provide impetus toward breeding efforts to develop cultivars with increased antioxidant capacity as ‘functional foods’.

Proximal composition, bioactive compounds and biorefinery approach in potato tubers ofSolanum tuberosumGroup Phureja: a review

Potato tubers of Group Phureja have a great relevance in terms of production and consumer acceptance in the Andean countries. However, its proximal characteristics, nutritional value and bioactive

Heritability of target bioactive compounds and hydrophilic antioxidant capacity in purple- and red-fleshed tetraploid potatoes

The high estimates of heritability support the main role of genetics in phytochemical composition and suggest that sufficient heritable genetic variation exists in tetraploid potato germplasm for the breeding of advanced clones with improved bioactive properties.

Potato Antioxidant Compounds: Impact of Cultivation Methods and Relevance for Diet and Health

The importance of potato in the diet is higher in developed as compared to developing countries, accounting for 130 kcal per person per day for the developed world and for 41 kcal per people per day in the developing world.

Biosynthesis and Engineering of Carotenoids and Apocarotenoids in Plants: State of the Art and Future Prospects

In this review, following a description of the general carotenoid pathway, select examples of plant species able to produce specialty carotanoids and apocarotenoids are illustrated.



Genetic engineering of a zeaxanthin-rich potato by antisense inactivation and co-suppression of carotenoid epoxidation.

Northern blot analysis demonstrated that upregulation of carotenogenesis in the transgenics is accompanied by substantial higher phytoene synthase transcript levels in 6-week-old tubers and a very slight increase of the beta-carotene hydroxylase transcript and the amount of the deoxyxylulose 5-phosphate synthase mRNA was very similar in wild type and transformed tubers.

Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi;Fructus barbarum L.)

Results showed clearly that homogenisation of wolfberry in hot skimmed milk results in a formulation that has a 3-fold enhanced bioavailability of zeaxanthin compared with both the ‘classical’ hot water and warm skimmed Milk treatment of the berries.

Incorporation of carotenoids from paprika oleoresin into human chylomicrons

The objective of the present study was to assess the availability of carotenoids from paprika oleoresin, including zeaxanthin, β-cryptoxanthin), β-carotene and the paprika-specific oxocarotenoid capsanthin and capsorubin.

Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention

As the evidence for a role of lutein and zeaxanthin in disease prevention continues to evolve, particularly from human studies directed to their bioavailability, metabolism, and dose-response relationships with intermediary biomarkers and clinical outcomes, it is worth noting that recommendations to consume foods rich in xanthophylls are consistent with current dietary guidelines.

Lutein, zeaxanthin, and the macular pigment.

Prospects for future research in the study of macular pigment require new initiatives that will probe more accurately into the localization of these carotenoids in the retina, identify possible transport proteins and mechanisms, and prove the veracity of the photoprotection hypothesis for the macular pigments.

Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.

Although increasing the intake of lutein or zeaxanthin might prove to be protective against the development of age-related macular degeneration, a causative relationship has yet to be experimentally demonstrated.

Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human.

  • C. GärtnerW. StahlH. Sies
  • Biology, Medicine
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1996
There is a preferential uptake of the xanthophylls lutein and zeaxanthin as compared to all-trans beta-carotene from the intestinal lumen into chylomicrons in the presence of high amounts of beta- carotene.

Intestinal absorption of β-carotene, lycopene and lutein in men and women following a standard meal: response curves in the triacylglycerol-rich lipoprotein fraction

Large inter-subject variation in TRL carotene uptake precluded any differences between sexes but surprising intra-subject consistency was observed in TR lutein-rich lipoprotein (TRL) β-carotenes uptake of three subjects.

Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers.

Intervention with tomato oleoresin extract resulted in significant increases in total plasma lycopene and resulted in decreased levels of DNA strand breaks of approximately 32 (non-smokers) and 39% (smokers), however, this effect was not statistically significant in either group.