Zearalenone-induced changes in biochemical parameters, oxidative stress and apoptosis in cardiac tissue: Protective role of crocin.

@article{Salem2016ZearalenoneinducedCI,
  title={Zearalenone-induced changes in biochemical parameters, oxidative stress and apoptosis in cardiac tissue: Protective role of crocin.},
  author={Intidhar Ben Salem and Manel Boussabbeh and Fadoua Neffati and Mohamed Fadhel Najjar and Salwa Abid-Essefi and Hassen Bacha},
  journal={Human & experimental toxicology},
  year={2016},
  volume={35 6},
  pages={623-34}
}
Zearalenone (ZEN) is a mycotoxin from Fusarium species commonly found in food commodities and is known to cause reproductive disorders. Several in vivo studies have shown that ZEN is haematotoxic and hepatotoxic and causes several alterations of immunological parameters. Meantime, the available information on the cardiotoxic effects of ZEN is very much limited. In the present study, we investigated the toxic effects of ZEN in heart tissues of Balb/c mice. We demonstrated that ZEN (40 mg kg(-1… CONTINUE READING