Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex.

@article{Nielsen2014Zbtb20DA,
  title={Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex.},
  author={Jakob V. Nielsen and Mads Thomassen and Kjeld M{\o}llg{\aa}rd and Jens Noraberg and Niels Aagaard Jensen},
  journal={Cerebral cortex},
  year={2014},
  volume={24 5},
  pages={
          1216-29
        }
}
Hippocampal pyramidal neurons are important for encoding and retrieval of spatial maps and episodic memories. While previous work has shown that Zbtb20 is a cell fate determinant for CA1 pyramidal neurons, the regulatory mechanisms governing this process are not known. In this study, we demonstrate that Zbtb20 binds to genes that control neuronal subtype specification in the developing isocortex, including Cux1, Cux2, Fezf2, Foxp2, Mef2c, Rorb, Satb2, Sox5, Tbr1, Tle4, and Zfpm2. We show that… 
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