Zardaverine as a selective inhibitor of phosphodiesterase isozymes.

@article{Schudt1991ZardaverineAA,
  title={Zardaverine as a selective inhibitor of phosphodiesterase isozymes.},
  author={Christian Schudt and Susanne Winder and B. Mueller and Dieter Ukena},
  journal={Biochemical pharmacology},
  year={1991},
  volume={42 1},
  pages={153-62}
}
The pyridazinone derivative zardaverine has recently been introduced as a potent bronchodilator in vivo and in vitro. In addition, zardaverine exerts a positive inotropic action on heart muscle in vitro. The actions of zardaverine are thought to be mediated via inhibition of phosphodiesterase (PDE) activity. Recent data suggest that there are multiple forms of phosphodiesterases and at least five different isozyme families are now recognized. In the present study, the effects of zardaverine on… CONTINUE READING
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