Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology

  title={Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology},
  author={Mengmeng Zhang and Jiaolong Wang and Lei Zhu and Tao Li and Weidong Jiang and Juan Zhou and Wei Peng and Chunjie Wu},
  journal={International Journal of Molecular Sciences},
Zanthoxylum bungeanum Maxim. (Rutaceae) is a popular food additive and traditional Chinese herbal medicine commonly named HuaJiao in China. This plant is widely distributed in Asian countries. The aim of this paper is to provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of this plant. Furthermore, the possible development and perspectives for future research on this plant are also discussed. To date, over 140 compounds… 

Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications

It was observed that many of the plant species are used as food ingredients and in treating inflammation, pain, hypertension and brain diseases and possess promising biological activities and should be further explored as potential sources of new nutraceuticals and drugs.

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs.

Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies

In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis.

Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)

Phytochemical screening of these extracts was carried out to determine the main classes of secondary metabolites present in Z. caribaeum, and indicated the presence of steroids, flavanone, flavones, flavonols, saponins, tannins, triterpenoids and xanthones.



Essential oil from Zanthoxylum bungeanum Maxim. and its main components used as transdermal penetration enhancers: a comparative study

Investigation of the skin penetration enhancement effect of Z. bungeanum oil and its main components on traditional Chinese medicine (TCM) active components suggested that these enhancers promoted the skin permeation of drugs mainly by affecting SC lipids.

Chemical Composition and Antifungal Activity of the Fruit Oil of Zanthoxylum bungeanum Maxim. (Rutaceae) from China

The results indicate that Z. bungeanum oil could be a source of antifungal ingredients for plant disease control especially applied in fruit and vegetable preservation.

Phytochemical Profiles and Antioxidant and Antimicrobial Activities of the Leaves of Zanthoxylum bungeanum

Z. bungeanum leaves have health benefits when consumed and could be served as an accessible source for production of functional food ingredients and medicinal exploration.

Purification and Characterization of Flavonoids from the Leaves of Zanthoxylum bungeanum and Correlation between Their Structure and Antioxidant Activity

Findings suggest that Z. bungeanum leaves may have health benefits when consumed and could become a useful supplement for pharmaceutical products and functional food ingredients in both nutraceutical and food industries as a potential source of natural antioxidants.

Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes.

The Chemical and Genetic Characteristics of Szechuan Pepper (Zanthoxylum bungeanum and Z. armatum) Cultivars and Their Suitable Habitat

The results indicated that the most suitable areas for producing Z. bungeanum cultivars ranged from the Hengduan Mountains to the Ta-pa Mountains, and the regions suitable for Z. armatum cultivars were found to be in the Sichuan Basin and Dalou-Wu mountains.

Polyphenolics composition of the leaves of Zanthoxylum bungeanum Maxim. grown in Hebei, China, and their radical scavenging activities.

The result shows that the polyphenols could reduce the ROS in HT-29 cells without cell toxicity and show good radical scavenging activities in DPPH and superoxide anion.

Aroma constituents and alkylamides of red and green huajiao (Zanthoxylum bungeanum and Zanthoxylum schinifolium).

  • Xiaogen Yang
  • Chemistry, Medicine
    Journal of agricultural and food chemistry
  • 2008
A new concept, "aroma character impact value" (ACI), is introduced as the percentage of the ratio of the concentration of an aroma component to its odor threshold value, which is described as having fresh, spicy, floral, cooling, and green aroma notes.

The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols.