Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology

@article{Zhang2017ZanthoxylumBM,
  title={Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology},
  author={M. Zhang and Jiao-Long Wang and Lei Zhu and T. Li and Weidong Jiang and J. Zhou and W. Peng and Chunjie Wu},
  journal={International Journal of Molecular Sciences},
  year={2017},
  volume={18}
}
Zanthoxylum bungeanum Maxim. (Rutaceae) is a popular food additive and traditional Chinese herbal medicine commonly named HuaJiao in China. This plant is widely distributed in Asian countries. The aim of this paper is to provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of this plant. Furthermore, the possible development and perspectives for future research on this plant are also discussed. To date, over 140 compounds… Expand
Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications
TLDR
It was observed that many of the plant species are used as food ingredients and in treating inflammation, pain, hypertension and brain diseases and possess promising biological activities and should be further explored as potential sources of new nutraceuticals and drugs. Expand
Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia
The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms againstExpand
Antagonistic interaction of phenols and alkaloids in Sichuan pepper (Zanthoxylum bungeanum) pericarp
Abstract The pericarp of Zanthoxylum bungeanum (PZB) is rich in phenols and alkaloids as a potential source of antioxidants, also known as Huajiao or Sichuan pepper in China, and is not onlyExpand
Chemical constituents from the pericarps of Zanthoxylum bungeanum and their chemotaxonomic significance
TLDR
The phytochemical study of the pericarps of Zanthoxylum bungeanum Maxim under the guidance of bioactivity led to the isolation of 18 compounds, including a new isobutylhydroxyamide and known compounds, i.e. cis-trans isomeric isOButylHydroxyamides, which were elucidated based on extensive spectroscopic methods and literature data. Expand
Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma.
TLDR
The hypothesis that ZBSO is a capable candidate for anti-melanoma agent is supported, and new insights for future work on investigating the utilization of Z BSO in malignant melanoma treatment are provided. Expand
Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies
TLDR
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Expand
Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)
TLDR
Phytochemical screening of these extracts was carried out to determine the main classes of secondary metabolites present in Z. caribaeum, and indicated the presence of steroids, flavanone, flavones, flavonols, saponins, tannins, triterpenoids and xanthones. Expand
A comparative overview on chili pepper (capsicum genus) and sichuan pepper (zanthoxylum genus): From pungent spices to pharma-foods
TLDR
A systematic comparison of structural and bioactivities diversity of bioactive ingredients from edible parts of two peppers are necessary to address their future application and more approaches should be conducted to overcome side effects of capsaicin during clinical application. Expand
Quality evaluation and chemometric discrimination of Zanthoxylum bungeanum Maxim leaves based on flavonoids profiles, bioactivity and HPLC-fingerprint in a common garden experiment
Abstract Zanthoxylum bungeanum leaves (ZBL) have rich flavonoids with a variety of bioactivities, which has great values of development and utilization. In this paper, the quality of thirteenExpand
Biotransformation of alkylamides and alkaloids by lactic acid bacteria strains isolated from Zanthoxylum bungeanum meal.
TLDR
This study introduced a reliable strategy for processing ZBM as a feed additive by using Lactobacillus paracasei and L. acidipiscis isolated from ZBM in solid-state fermentation of ZBM to reduce the concentration of undesirable alkylamides and alkaloids. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 118 REFERENCES
Phytochemical profiles and biological activity evaluation of Zanthoxylum bungeanum Maxim seed against asthma in murine models.
TLDR
The murine models demonstrated that ZBMS displays a protective effect on guinea pig sensitization, a dose-dependent inhibition of the increases in RL and decreases in Cdyn, which resulted in the relief of auricle edema and toe swelling in mice and anti-stress activity. Expand
Essential oil from Zanthoxylum bungeanum Maxim. and its main components used as transdermal penetration enhancers: a comparative study
  • Y. Lan, H. Li, +4 authors Q. Wu
  • Chemistry, Medicine
  • Journal of Zhejiang University SCIENCE B
  • 2014
TLDR
Investigation of the skin penetration enhancement effect of Z. bungeanum oil and its main components on traditional Chinese medicine (TCM) active components suggested that these enhancers promoted the skin permeation of drugs mainly by affecting SC lipids. Expand
Chemical Composition and Antifungal Activity of the Fruit Oil of Zanthoxylum bungeanum Maxim. (Rutaceae) from China
TLDR
The results indicate that Z. bungeanum oil could be a source of antifungal ingredients for plant disease control especially applied in fruit and vegetable preservation. Expand
Phytochemical Profiles and Antioxidant and Antimicrobial Activities of the Leaves of Zanthoxylum bungeanum
TLDR
Z. bungeanum leaves have health benefits when consumed and could be served as an accessible source for production of functional food ingredients and medicinal exploration. Expand
Purification and Characterization of Flavonoids from the Leaves of Zanthoxylum bungeanum and Correlation between Their Structure and Antioxidant Activity
TLDR
Findings suggest that Z. bungeanum leaves may have health benefits when consumed and could become a useful supplement for pharmaceutical products and functional food ingredients in both nutraceutical and food industries as a potential source of natural antioxidants. Expand
Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes.
TLDR
ZBEO inhibits the proliferation of HaCaT cells, resulting from the induction of cellular apoptosis through both intrinsic and extrinsic pathways, and is a potential candidate that may be considered for development into an anti-psoriasis drug. Expand
The Chemical and Genetic Characteristics of Szechuan Pepper (Zanthoxylum bungeanum and Z. armatum) Cultivars and Their Suitable Habitat
TLDR
The results indicated that the most suitable areas for producing Z. bungeanum cultivars ranged from the Hengduan Mountains to the Ta-pa Mountains, and the regions suitable for Z. armatum cultivars were found to be in the Sichuan Basin and Dalou-Wu mountains. Expand
Polyphenolics composition of the leaves of Zanthoxylum bungeanum Maxim. grown in Hebei, China, and their radical scavenging activities.
TLDR
The result shows that the polyphenols could reduce the ROS in HT-29 cells without cell toxicity and show good radical scavenging activities in DPPH and superoxide anion. Expand
Aroma constituents and alkylamides of red and green huajiao (Zanthoxylum bungeanum and Zanthoxylum schinifolium).
  • Xiaogen Yang
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 2008
TLDR
A new concept, "aroma character impact value" (ACI), is introduced as the percentage of the ratio of the concentration of an aroma component to its odor threshold value, which is described as having fresh, spicy, floral, cooling, and green aroma notes. Expand
The effects of Zanthoxylum bungeanum extract on lipid metabolism induced by sterols.
TLDR
This study indicated that ZBBu could regulate the lipid metabolism through increasing the amount of low density lipoprotein receptor (LDLR) protein and inducing the expression of genes involved in RCT. Expand
...
1
2
3
4
5
...