Zaleplon and triazolam in humans: acute behavioral effects and abuse potential

@article{Rush1999ZaleplonAT,
  title={Zaleplon and triazolam in humans: acute behavioral effects and abuse potential},
  author={Craig R Rush and Jeannie Frey and Roland R. Griffiths},
  journal={Psychopharmacology},
  year={1999},
  volume={145},
  pages={39-51}
}
Zaleplon, a pyrazolopyrimidine that is under development as a hypnotic, produces its pharmacological effects at the benzodiazepine-recognition site on the GABAA benzodiazepine-receptor complex. Unlike most benzodiazepines, zaleplon binds selectively to the BZ1 (ω1) subtype of the benzodiazepine receptor. The present study compared the acute subject-rated effects, performance-impairing effects, and abuse potential of zaleplon and triazolam, a triazolobenzodiazepine hypnotic, in 14 healthy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Mass balance and pharmacokinetics of zaleplon, a non-benzodiazepine sedative/hypnotic, in man

WH Wu, AT DiCioccio, +3 authors PR Mayer
Pharm Res 13: S487, • 1996
View 3 Excerpts
Highly Influenced

Zolpidem and triazolam in humans: behavioral and subjective effects and abuse liability.

The Journal of pharmacology and experimental therapeutics • 1990
View 3 Excerpts
Highly Influenced

Comparison of triazolam and pentobarbital: performance impairment, subjective effects and abuse liability.

The Journal of pharmacology and experimental therapeutics • 1985
View 5 Excerpts
Highly Influenced

Behavioral Pharmacology of Zolpidem Relative to Benzodiazepines: A Review

Pharmacology Biochemistry and Behavior • 1998
View 1 Excerpt

Similar Papers

Loading similar papers…