Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats.

  title={Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats.},
  author={Leith C. R. Meyer and Andrea Fuller and Duncan Mitchell},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={290 2},
  • L. MeyerA. FullerD. Mitchell
  • Published 1 February 2006
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Neurophysiological studies have shown that serotonergic ligands that bind to 5-HT1A, 5-HT7, and 5-HT4 serotonin receptors in brain stem have beneficial effects on respiratory neurons during opioid-induced respiratory depression. The effect of these ligands on respiratory function and pulmonary performance has not been studied. We therefore examined the effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), an agonist of 5-HT1A and 5-HT7 receptors, and zacopride, an agonist of 5-HT4… 

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