Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats.

@article{Meyer2006ZacoprideA8,
  title={Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats.},
  author={Leith C R Meyer and Andrea Fuller and Duncan Mitchell},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 2},
  pages={
          R405-13
        }
}
  • Leith C R Meyer, Andrea Fuller, Duncan Mitchell
  • Published in
    American journal of…
    2006
  • Chemistry, Medicine
  • Neurophysiological studies have shown that serotonergic ligands that bind to 5-HT1A, 5-HT7, and 5-HT4 serotonin receptors in brain stem have beneficial effects on respiratory neurons during opioid-induced respiratory depression. The effect of these ligands on respiratory function and pulmonary performance has not been studied. We therefore examined the effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), an agonist of 5-HT1A and 5-HT7 receptors, and zacopride, an agonist of 5-HT4… CONTINUE READING

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