ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone.

@article{Roy1993ZR751BC,
  title={ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone.},
  author={Robert J. Le Roy and Alain B{\'e}langer},
  journal={Endocrinology},
  year={1993},
  volume={133 2},
  pages={683-9}
}
Fatty acid esters of dehydroepiandrosterone (DHEA-FA) are present in the circulation, although no physiological function has yet been attributed to these metabolites. They are formed directly in serum and are predominantly localized in association with lipoproteins. The objective of this study was to determine the capacity of these lipoprotein-incorporated DHEA metabolites to generate nonconjugated steroids after incubation with cells in culture. A method for studying DHEA-FA using a… CONTINUE READING