ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.

@article{Hernandez2007ZO2SI,
  title={ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.},
  author={Sandra Hernandez and Bibiana Chavez Munguia and Lorenza Gonz{\'a}lez-Mariscal},
  journal={Experimental cell research},
  year={2007},
  volume={313 8},
  pages={1533-47}
}
ZO-2 is a tight junction (TJ) protein that shuttles between the plasma membrane and the nucleus. ZO-2 contains several protein binding sites that allow it to function as a scaffold that clusters integral, adaptor and signaling proteins. To gain insight into the role of ZO-2 in epithelial cells, ZO-2 was silenced in MDCK cells with small interference RNA (siRNA). ZO-2 silencing triggered: (A) changes in the gate function of the TJ, determined by an increase in dextran flow through the… CONTINUE READING

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