ZO-2 induces cytoplasmic retention of YAP by promoting a LATS1-ZO-2-YAP complex at tight junctions

@article{Liu2018ZO2IC,
  title={ZO-2 induces cytoplasmic retention of YAP by promoting a LATS1-ZO-2-YAP complex at tight junctions},
  author={Olivia Xuan Liu and L. Lin and T. Chew and Fumio Motegi and B. C. Low},
  journal={bioRxiv},
  year={2018}
}
  • Olivia Xuan Liu, L. Lin, +2 authors B. C. Low
  • Published 2018
  • Chemistry, Biology
  • bioRxiv
  • Contact inhibition of proliferation (CIP) is a key mechanism that transduces the cell density status of tissue and organs into a unique transcriptional program by translocating YAP between the nucleus and the cytoplasm. However, the nature of the cell density-dependent cues that regulate the YAP distribution remains unclear. Here, we present evidence that tight junctions serve as a platform that controls both distribution and activity of LATS1, a kinase that phosphorylates YAP. This CIP effect… CONTINUE READING
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