ZO-1 maintains its spatial distribution but dissociates from junctional fibrils during tight junction regulation.

@article{Madara1993ZO1MI,
  title={ZO-1 maintains its spatial distribution but dissociates from junctional fibrils during tight junction regulation.},
  author={James L. Madara and Susan L. Carlson and James Melvin Anderson},
  journal={The American journal of physiology},
  year={1993},
  volume={264 5 Pt 1},
  pages={C1096-101}
}
Tight junctions restrict diffusion of hydrophilic solutes through the paracellular pathways of columnar epithelia. It is now apparent that the barrier function of tight junctions is physiologically regulated. Current models of the tight junction envisage junctional subunits consisting of extracellular "kisses" between plasma membranes of adjacent cells, intramembrane components represented by freeze-fracture fibrils, and cytoplasmic elements of the cytoskeleton. Insights into functional… CONTINUE READING

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