ZO-1 determines adherens and gap junction localization at intercalated disks.

@article{Palatinus2011ZO1DA,
  title={ZO-1 determines adherens and gap junction localization at intercalated disks.},
  author={Joseph A. Palatinus and Michael P. O'Quinn and Ralph J. Barker and B. A. Sarah Harris and Jane Jourdan and Robert G Gourdie},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={300 2},
  pages={
          H583-94
        }
}
The disruption of the spatial order of electromechanical junctions at myocyte-intercalated disks (ICDs) is a poorly understood characteristic of many cardiac disease states. Here, in vitro and in vivo evidence is provided that zonula occludens-1 (ZO-1) regulates the organization of gap junctions (GJs) and adherens junctions (AJs) at ICDs. We investigated the contribution of ZO-1 to cell-cell junction localization by expressing a dominant-negative ZO-1 construct (DN-ZO-1) in rat ventricular… CONTINUE READING

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