ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

@article{Umeda2006ZO1AZ,
  title={ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation},
  author={Kazuaki Umeda and Junichi Ikenouchi and Sayaka Katahira-Tayama and Kyoko Furuse and Hiroyuki Sasaki and Mayumi Nakayama and Takeshi Matsui and Sachiko Tsukita and Mikio Furuse and Shoichiro Tsukita},
  journal={Cell},
  year={2006},
  volume={126},
  pages={741-754}
}
  • Kazuaki Umeda, Junichi Ikenouchi, +7 authors Shoichiro Tsukita
  • Published 2006
  • Biology, Medicine
  • Cell
  • A fundamental question in cell and developmental biology is how epithelial cells construct the diffusion barrier allowing them to separate different body compartments. Formation of tight junction (TJ) strands, which are crucial for this barrier, involves the polymerization of claudins, TJ adhesion molecules, in temporal and spatial manners. ZO-1 and ZO-2 are major PDZ-domain-containing TJ proteins and bind directly to claudins, yet their functional roles are poorly understood. We established… CONTINUE READING

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    Junctional adhesion molecule (JAM) binds to PAR-3

    VIEW 1 EXCERPT