ZNF76, a Novel Transcriptional Repressor Targeting TATA-binding Protein, Is Modulated by Sumoylation*

@article{Zheng2004ZNF76AN,
  title={ZNF76, a Novel Transcriptional Repressor Targeting TATA-binding Protein, Is Modulated by Sumoylation*},
  author={G. Zheng and Yu-Chung Yang},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={42410 - 42421}
}
Direct interaction of positive and negative regulators with the general transcription machinery modulates transcription. The TATA-binding protein (TBP) is one target for transcriptional regulators. In this study, we identified ZNF76 as a novel transcriptional repressor that targets TBP. ZNF76 interacts with TBP through both its N and C termini, and both regions are required for ZNF76 to exert its inhibitory function on p53-mediated transactivation. The inhibitory effect of ZNF76 on p53 activity… Expand
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