ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.

  title={ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.},
  author={Ulla Karvonen and Tiina J{\"a}{\"a}skel{\"a}inen and Miia M. Rytinki and Sanna Kaikkonen and Jorma J. Palvimo},
  journal={Journal of molecular biology},
  volume={382 3},
Covalent modification by small ubiquitin-related modifiers (SUMOs) is an important means to regulate dynamic residency of transcription factors within nuclear compartments. Here, we identify a multi-C(2)H(2)-type zinc finger protein (ZNF), ZNF451, as a novel nuclear protein that can be associated with promyelocytic leukemia bodies. In keeping with its interaction with SUMO E2 conjugase Ubc9 and SUMOs, ZNF451 is covalently modified by SUMOs (sumoylated) at several, albeit nonconsensus, sites… CONTINUE READING


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