ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.

  title={ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.},
  author={Shinsuke Hirabayashi and Kentaro Ohki and Kazuhiko Nakabayashi and Hitoshi Ichikawa and Yukihide Momozawa and Kohji Okamura and Akinori Yaguchi and Kazuki Terada and Yuya Saito and Ai Yoshimi and Hiroko Ogata-Kawata and Hiromi Sakamoto and Motohiro Kato and Junya Fujimura and Moeko Hino and Akitoshi Kinoshita and Harumi Kakuda and Hidemitsu Kurosawa and Keisuke Kato and Ryosuke Kajiwara and Koichi Moriwaki and Tsuyoshi Morimoto and Kozue Nakamura and Yasushi Noguchi and Tomoo Osumi and Kazuo Sakashita and Junko Takita and Yuki Yuza and Koich Matsuda and Teruhiko Yoshida and Kenji Matsumoto and Kenichiro Hata and Michiaki Kubo and Yoichi Matsubara and Takashi Fukushima and Katsuyoshi Koh and Atsushi Manabe and Akira Ohara and Nobutaka Kiyokawa},
  volume={102 1},
Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners have been reported. We further characterized this type of fusion gene by whole transcriptome sequencing and/or polymerase chain reaction. In addition to previously reported genes, we identified BMP2K as a novel fusion partner for ZNF384 Including the EP300-ZNF384 that we reported recently, the total frequency of ZNF384-related fusion genes was 4.1% in 291 B-cell… CONTINUE READING
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