ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death

@inproceedings{Li2015ZNF32IA,
  title={ZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death},
  author={Yanyan Li and Le Zhang and Kai Li and Jun Li and Rong Xiang and Jie Zhang and Hongjiang Li and Yan Xu and Yuyan Wei and Junping Gao and Ping Lin and Yu-Quan Wei},
  booktitle={Scientific reports},
  year={2015}
}
ZNF32 is a recently identified zinc finger protein and its functions remain largely unknown. Autophagy has been shown to affect cell proliferation and survival. Here, we innovatively show the effect of ZNF32 on cell autophagy and autophagy-associated cell death in breast carcinoma cells and also elucidate its underlying mechanisms. We examined the autophagic activity and LC3 II expression in human carcinoma cell lines with increased or decreased ZNF32 expression. Pharmacological inhibition… CONTINUE READING
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