ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.

@article{Huang2005ZNF217SC,
  title={ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.},
  author={Guiqing Huang and Sheryl R. Krig and David Kowbel and Hongmei Xu and Bill Hyun and Stanislav Volik and Burt Feuerstein and Gordon B. Mills and David Stokoe and Paul Yaswen and Colin Collins},
  journal={Human molecular genetics},
  year={2005},
  volume={14 21},
  pages={3219-25}
}
Chromosome 20q13.2 is amplified in 20-30% of early-stage breast tumors and is associated with poor prognosis. Detailed mapping of the amplified region using molecular cytogenetics, positional cloning and genomic sequencing culminated in a detailed molecular description of the candidate oncogene ZNF217. ZNF217 proteins resemble Kruppel-like transcription factors, localize predominately to the nucleus and associate with proteins involved in transcriptional repression. The findings that ZNF217 can… CONTINUE READING