ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.

@article{Zhang2010ZIP4RP,
  title={ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.},
  author={Yuqing Zhang and Uddalak Bharadwaj and Craig D. Logsdon and Changyi Johnny Chen and Q. -S. Yao and Min Li},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 5},
  pages={1423-30}
}
PURPOSE Recent studies indicate a strong correlation of zinc transporter ZIP4 and pancreatic cancer progression; however, the underlying mechanisms are unclear. We have recently found that ZIP4 is overexpressed in pancreatic cancer. In this study, we investigated the signaling pathway through which ZIP4 regulates pancreatic cancer growth. EXPERIMENTAL DESIGN The expression of cyclin D1, interleukin 6 (IL-6), and signal transducer and activator of transcription 3 (STAT3) in pancreatic cancer… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

IL-6 stimulates Th2 type Clin Cancer Res

LW Feurino, Y Zhang, U Bharadwaj
Cancer Biol Ther 2007;6:1096–100 • 2010
View 1 Excerpt

Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 2 Excerpts

Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 6 Excerpts

Similar Papers

Loading similar papers…