ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.

@article{Nam2013ZIP14AD,
  title={ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.},
  author={Hyeyoung Nam and Chia-Yu Wang and Lin Zhang and Wei Zhang and Shintaro Hojyo and Toshiyuki Fukada and Mitchell D Knutson},
  journal={Haematologica},
  year={2013},
  volume={98 7},
  pages={
          1049-57
        }
}
The liver, pancreas, and heart are particularly susceptible to iron-related disorders. These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload. Here, we assessed the effect of iron status on the levels of the transmembrane transporters, ZRT/IRT-like protein 14 and divalent metal-ion transporter-1, which have both been implicated in transferrin- and non-transferrin-bound iron uptake. Weanling male rats (n=6/group) were fed an iron… CONTINUE READING

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