ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.

Abstract

Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient's likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) that are strong inducers of epithelial differentiation and inhibitors of stem cell factors. Given that each… (More)
DOI: 10.1172/JCI63608

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Cite this paper

@article{Ahn2012ZEB1DP, title={ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.}, author={Youngho Ahn and Don L. Gibbons and Deepavali Chakravarti and Chad J Creighton and Zain H. Rizvi and Henry Adams and Alexander Pertsemlidis and Philip A. Gregory and Josephine Anne Wright and Gregory J. Goodall and E. R. Rodrı́guez - Flores and Jonathan M. Kurie}, journal={The Journal of clinical investigation}, year={2012}, volume={122 9}, pages={3170-83} }