ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.

  title={ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.},
  author={Jill Everland Larsen and Vaishnavi Nathan and Jihan K. Osborne and Rebecca K Farrow and Dhruba Deb and James P. Sullivan and Patrick D Dospoy and Alexander Augustyn and Suzie K Hight and Mitsuo Sato and Luc Girard and Carmen Behrens and Ignacio I. Wistuba and Adi F. Gazdar and N. K. Hayward and John D. Minna},
  journal={The Journal of clinical investigation},
  volume={126 9},
Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer pathogenesis. Specific oncogenic mutations in TP53 and KRAS were required for HBECs to engage EMT… CONTINUE READING
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