ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer.

@article{Hill2013ZEBmiR200FL,
  title={ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer.},
  author={Louise Hill and Gareth Browne and Eugene Tulchinsky},
  journal={International journal of cancer},
  year={2013},
  volume={132 4},
  pages={745-54}
}
Embryonic differentiation programs of epithelial-mesenchymal and mesenchymal-epithelial transition (EMT and MET) represent a mechanistic basis for epithelial cell plasticity implicated in cancer. Transcription factors of the ZEB protein family (ZEB1 and ZEB2) and several microRNA species (predominantly miR-200 family members) form a double negative feedback loop, which controls EMT and MET programs in both development and tumorigenesis. In this article, we review crosstalk between the ZEB/miR… CONTINUE READING