ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells.

@article{SnchezAlonso2008ZD7I,
  title={ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells.},
  author={Jos{\'e} Luis S{\'a}nchez-Alonso and James V Halliwell and Asunci{\'o}n Colino},
  journal={Neuroscience letters},
  year={2008},
  volume={439 3},
  pages={275-80}
}
Many studies have used the channel blocker ZD 7288 to assess possible physiological and pathophysiological roles of hyperpolarization-activated cation currents (Ih). In view of the known interplay between Ih and other membrane conductances, the effects in Wistar rats of ZD 7288 on low-voltage-activated (LVA (- or T-type)) Ca2+ channels were examined in whole-cell patch-clamp recordings from CA1 pyramidal cells in the presence of TTX, TEA, 4-AP, CsCl, BaCl2 and nifedipine. ZD 7288 reduced T-type… CONTINUE READING

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