ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation

  title={ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation},
  author={Luise Hartmann and Sayantanee Dutta and Sabrina Opatz and Sebastian Vosberg and Katrin Reiter and Georg Leubolt and Klaus H Metzeler and Tobias Herold and Stefanos A. Bamopoulos and Kathrin Br{\"a}undl and Evelyn Zellmeier and Bianka Ksienzyk and Nikola P. Konstandin and Stephanie Schneider and Karl-Peter Hopfner and Alexander Graf and Stefan Krebs and Helmut Blum and Jan M Middeke and Friedrich St{\"o}lzel and Christian Thiede and Stephan Wolf and Stefan K Bohlander and Caroline Preiss and Linping Chen-Wichmann and Christian Wichmann and Maria Cristina Sauerland and Thomas B{\"u}chner and Wolfgang E. Berdel and Bernhard Josef W{\"o}rmann and Jan Braess and Wolfgang Hiddemann and Karsten Spiekermann and Philipp A. Greif},
  booktitle={Nature communications},
The t(8;21) translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukaemia (AML) and results in the RUNX1/RUNX1T1 rearrangement. Despite the causative role of the RUNX1/RUNX1T1 fusion gene in leukaemia initiation, additional genetic lesions are required for disease development. Here we identify recurring ZBTB7A mutations in 23% (13/56) of AML t(8;21) patients, including missense and truncating mutations resulting in alteration or loss of the C-terminal zinc… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS
5 Citations
33 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 33 references

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

  • M Higuchi
  • Cancer Cell 1,
  • 2002
Highly Influential
10 Excerpts

Similar Papers

Loading similar papers…